A study published inJAMA Dermatolshowed that diflucan, a fluconazole antifungal medication, was associated with a 1.7-fold increased risk of skin and nail yeast infections compared to placebo.1,2
A review of 15,091 cases of dermatologic fungal infections in women treated with fluconazole suggested that the drug had a protective effect on dermatophytes.2,3
In this study, researchers looked at data from a large population-based study of fluconazole (generic name Diflucan) that was conducted in France between 2002 and 2004. They found that women who used the drug had a 1.7-fold increased risk for a skin and nail yeast infection compared to placebo, and this risk was associated with use of the drug in women who had a vaginal yeast infection. The risk of fungal infection was not associated with the use of fluconazole in women who had no other risk factors for the infection.
The study also showed that the risk of fungal infection among women using fluconazole was higher than among women using oral fluconazole or an oral antifungal treatment. However, the risk was not associated with the use of fluconazole in women who had vaginal yeast infections, so it is unclear whether this risk is related to the use of fluconazole in women who have a vaginal yeast infection.
In contrast, researchers looked at data from a large cohort study of women that included women who had vaginal yeast infections, and found no increased risk of vaginal yeast infections compared to women who had a vaginal yeast infection.2,4
The researchers also did an analysis of the data from the French National Surveillance of Vaginal Yeast Infections, which had a similar design and included women who had vaginal yeast infections, but also found no increased risk of vaginal yeast infections.2
In contrast, the French National Surveillance of Vaginal Yeast Infections reported that the risk of vaginal yeast infections was not associated with vaginal or oral fluconazole use, and so the researchers looked at the data from the French National Surveillance of Vaginal Yeast Infections.
In this study, researchers analyzed the data of the French National Surveillance of Vaginal Yeast Infections to compare the risk of vaginal yeast infections with fluconazole use and oral or topical fluconazole use.
They found that the risk of vaginal yeast infections was not increased by fluconazole use in women who had vaginal or oral fluconazole or fluconazole.2
They also found no increased risk of vaginal yeast infections among women using oral fluconazole.2
The French National Surveillance of Vaginal Yeast Infections included data from 15,091 women, who had vaginal yeast infections, and found no increased risk of vaginal yeast infections compared to women who had a vaginal yeast infection.
The researchers also found no increased risk of vaginal yeast infections among women who had oral or topical fluconazole use.
The researchers used a review of the data from the French National Surveillance of Vaginal Yeast Infections to evaluate the risk of vaginal yeast infections among women who had vaginal or oral fluconazole or fluconazole use.
The researchers looked at data from 15,091 cases of vaginal yeast infections, and found that the risk of vaginal yeast infections was not increased by vaginal fluconazole use in women who had vaginal or oral fluconazole or fluconazole use.2
The researchers also looked at data from a large cohort study of women that included women who had vaginal or oral fluconazole or fluconazole use, but also found no increased risk of vaginal yeast infections.
The French National Surveillance of Vaginal Yeast Infections included data from 15,091 cases of vaginal yeast infections, and found no increased risk of vaginal yeast infections among women who had vaginal or oral fluconazole or fluconazole use.
In addition, the French National Surveillance of Vaginal Yeast Infections reported that the risk of vaginal yeast infections was not associated with vaginal fluconazole use, and so the researchers looked at the data from the French National Surveillance of Vaginal Yeast Infections.
1. Clinical Trials Experience
1,2 Trials were conducted in the United States of America (AOMA), France, Germany, the Netherlands, Norway, Poland, Portugal, and Taiwan (3). The AOMA Clinical Trials Experience database (4) is an integrated clinical trial platform providing data on randomized, double-blind, placebo-controlled, phase III clinical trials conducted to assess the efficacy and safety of fluconazole (3). Patients enrolled in these studies were randomly assigned to receive either diflucan (4 mg/day) or placebo (10 mg/day) for at least 1 year. At the end of each study period, patients were randomized to receive either diflucan or placebo for 12 weeks. The primary endpoint of this primary endpoint was the incidence of adverse events (AEs). The secondary endpoints were the incidence of discontinuations due to adverse events (AEs), adverse drug reaction (ADR), or death. For the purpose of this study, diflucan was chosen for clinical efficacy because it is FDA approved for the treatment of UTI (4), for which it is FDA approved for the treatment of candidemia (4), and for the treatment of candidemia associated with cryptococcal meningitis (4), anorexia (4), and purulent (4). Because of its safety profile, diflucan is generally considered the safest option for use for these patients, and patients who have an underlying medical condition that requires a high-dose regimen may be better candidates for the treatment of their UTI.
1,3,4,5 In patients with UTI, the incidence of adverse events was significantly higher in the diflucan group (14.6% vs 5.7%; hazard ratio, 0.73; 95% confidence interval [CI], 0.52-1.13; P =.01). This difference was significant for all the groups except for the diflucan group (2.6% vs 2.3%; hazard ratio, 1.04; 95% CI, 0.55-2.29; P =.06). These data were not statistically significant for the other groups except for the diflucan group (3.4% vs 2.0%; hazard ratio, 1.11; 95% CI, 0.44-4.01; P =.09). The incidence of ADRs in the diflucan group was significantly higher than the placebo group (15.0% vs 10.6%; hazard ratio, 1.2; 95% CI, 0.48-3.47; P =.06). These data were not statistically significant for the other groups except for the diflucan group (3.5% vs 2.0%; hazard ratio, 0.84; 95% CI, 0.39-4.29; P =.14). Although no deaths or ADRs were associated with diflucan use, the incidence of these events was higher in the diflucan group than in the placebo group (3.5% vs 2.0%; hazard ratio, 1.14; 95% CI, 0.56-3.28; P =.14).
2,4,5 In patients with UTI, the incidence of adverse events was significantly higher in the diflucan group (14.6% vs 5.7%; hazard ratio, 1.73; 95% CI, 0.59-8.16; P =.01) and was not statistically significant for the other groups except for the diflucan group (2.6% vs 2.3%; hazard ratio, 1.05; 95% CI, 0.45-2.82; P =.74). The incidence of ADRs was significantly higher in the diflucan group than in the placebo group (3.5% vs 2.0%; hazard ratio, 1.11; 95% CI, 0.44-4.02; P =.19). The incidence of ADRs was significantly higher in the diflucan group than in the placebo group (3.5% vs 2.0%; hazard ratio, 0.84; 95% CI, 0.39-4.29; P =.14).
3,4,5 To the best of our knowledge, no study has evaluated diflucan use for patients with UTI in the United States (AOMA). However, we do know that diflucan is generally considered the safest option for the treatment of UTI. Patients who have an underlying medical condition that requires a high-dose regimen may be better candidates for the treatment of their UTI.
Table 1.
When you have a yeast infection, it helps to know that there's a fast and simple way to treat it. Diflucan One is a trusted treatment that's clinically proven to relieve the itching, burning and discharge associated with vaginal yeast infections. So whether this is the first time you've had a vaginal yeast infection, or it's the first time you're trying Diflucan One, the information below will tell you what you need to know about the #1 brand prescribed by doctors in Canada for the treatment of yeast infections.
Diflucan One is a 1-pill, 1-dose, 1-day treatment that is clinically proven to cure most yeast infections. It can be taken anytime, anywhere, and it starts to relieve your symptoms in just one day.
Diflucan One works by stopping the growth of the fungi that caused the yeast infection in the first place. Although you only need to take one pill, the medication in Diflucan One, fluconazole 150 mg, continues working in your body for several days until your yeast infection is cured. You'll notice your symptoms begin to disappear within 24 hours and within 7 days they should be gone completely. If your symptoms have not improved within 3 days and have not completely disappeared within 7 days, contact your doctor.
How it's taken:Talk to your doctor or pharmacist before taking Diflucan One if:
These are not all the special precautions that can be taken to avoid getting them from your doctor.
Diflucan Tablet is used to treat fungal infections such as thrush, pneumonia, bronchitis, cervicitis, chlamydia, and gonorrhea. It is also used to prevent candidiasis in women and children.
Diflucan Tablet is used to treat thrush and vaginal thrush in women.
Diflucan Tablet is also used to prevent candidiasis in children, as candidiasis is a sexually transmitted disease.
Diflucan Tablet is used to treat thrush, pain, and inflammation of the vagina, cervix, and vulva. It may be used by women only if a doctor has told you it is not safe for them. It may be used in the treatment of a wide variety of fungal infections, like:
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them.
Serious side effects may include:
Diflucan Tablet should not be given to children, pregnant women and lactating mothers unless directed by a doctor.
Do not use Diflucan Tablet if you are allergic to it or to any of the ingredients in it. Do not take Diflucan Tablet if you are allergic to any of the other ingredients in it. It may cause drowsiness, dizziness, or fainting while driving.
Diflucan Tablet may cause drowsiness in some people. If you notice any of the following symptoms, do not drive or perform any activities that need mental alertness such as driving or operating machinery until you know how Diflucan Tablet affects you:
Store Diflucan Tablet at room temperature between 59 and 86 degrees F (15 and 30 degrees C). Do not store above 25 degrees C.
This product is a prescription drug. You will receive a newsletter from our sales team every time you refill your prescription. This is to let us know you have been successful in filling your prescription. As this is a prescription drug, we cannot send newsletters to these people.